The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm
نویسندگان
چکیده
منابع مشابه
Germ Plasm: Protein Degradation in the Soma
Germ plasm is a specialized cytoplasm that is physically segregated to the germline cells during early embryogenesis. Recent results suggest that, in Caenorhabditis elegans, germ plasm is also prevented from accumulating in somatic lineages by a ubiquitin ligase that targets germ plasm proteins for degradation.
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15 صفحه اولArginine methylation of Aubergine mediates Tudor binding and germ plasm localization.
Piwi proteins such as Drosophila Aubergine (Aub) and mouse Miwi are essential for germline development and for primordial germ cell (PGC) specification. They bind piRNAs and contain symmetrically dimethylated arginines (sDMAs), catalyzed by dPRMT5. PGC specification in Drosophila requires maternal inheritance of cytoplasmic factors, including Aub, dPRMT5, and Tudor (Tud), that are concentrated ...
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IRES-mediated translation of key cell fate regulating genes has been implicated in tumorigenesis. Concerted action of canonical eukaryotic initiation factors and IRES transacting factors (ITAFs) was shown to regulate cellular IRES mediated translation; however, the precise molecular mechanism of ribosome recruitment to cellular IRESes remains unclear. Here we show that the X-linked inhibitor of...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2020
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-020-0294-9